Written by: Vinzenz Schmid | Posted by: NootBot editorial staff
In modern times people often have to withstand stress and productivity is higher than ever before. With the industrialization everything got faster and faster. Our machines are steadily improved and our boundaries stretched day by day. But how can we as human beings survive in such an achievement-oriented society? How can we deliver faster and better results without risking diseases like a burnout? In the last few years so called “smart drugs” like Ritalin and Adderall have gained popularity.
More and more people tend to push themselves with those stimulants in order to come up with the results they are expected to show. The downside of those stimulants is that they usually have a large amount of negative side effects. They may be effective in short periods but on the long run it’s not the best option. So what is the alternative?
Nootropics! In the seventies the Romanian chemist dr. Corneliu Giurgea first synthesized a substance later called Piracetam. He discovered that there were improvements in the brains of the lab animals. Later he found out that those effects occurred with humans as well. Patients with a concussion recovered faster and showed improvements in their memory. There were no signs of toxicity in the human trials. The first nootropic was invented. By his definition nootropics were substances that improve cognitive functions and possess low toxicity. But what are nootropics in general?
Nootropics are natural products or chemically synthesized compounds with certain benefits for your brain. The brain’s weight is only small compared to the rest of our body but it needs one fifth of our daily calorie consumption. Processes like learning, focusing on tasks or mental exercise in general require large amounts of energy. That’s where nootropics can help you in different ways and won’t have the negative side effects of stimulants. Because of that you can take them for long periods and experience improvement over time.
There are different mechanisms how nootropics act. Certain substances like N-Acetyl-L-Carnitine can increase the energy delivery to your brain. With other supplements you can improve the blood flow to your brain and thereby the delivery of glucose, nutrients and oxygen. But nootropics are also great if you want to protect your brain and nervous system from aging or getting damaged in general. Some substances can even enhance the plasticity of your brain by supporting it to create new neural connections. Because of all these benefits nootropics are often used in the treatment of Alzheimer or memory impairment in general. But also for healthy young adults these substances have a lot to offer. The benefits can even be greater if you combine several nootropics and create a stack.
If you stack several substances together you can improve the effect and decrease possible side effects. There are many possible combinations for goals like better focus, energy, sleep, anti-anxiety and many more. In general, you start with one nootropic and continuously add others to check your tolerance. The most common stack is the combination of caffeine and the amino acid L-Theanine. Caffeine boosts your energy and alertness, L-Theanine helps you to focus, calm down and reduces possible side effects like jitteriness or anxiety caused by caffeine. This is just one of many examples of how a stack can deliver even better results than a single substance.
Most nootropics have only few or no side effects. But of course there are others where you have to be more careful. Ashwagandha has an influence on your thyroid so you should either cycle the consumption or check your thyroid levels regularly. In the majority of cases there are only small side effects like an upset stomach, fatigue or headaches. Nevertheless, you always have to be careful when taking a new substance. All in all, nootropics have more to offer than they harm you. That’s why it’s recommended to always check the substances, find reliable vendors and start with low doses.
Racetams - The Most Popular Nootropic Family
Written by: Peter Jamnik | Posted by: NootBot Editorial Staff
Piracetam, Aniracetam, Oxiracetam, Pramiracetam, Nefiracetam and Phenylpiracetam are best known nootropics from the racetam family, which concludes 19 different racetam supplements. They are known for improving mood, focus, learning, energy and memory, by stimulating the Acetylcholine receptors. Some racetams also improve an uptake of glutamate by activating NMDA and AMPA receptors.
Usually using racetams alone, they can cause different side effects, such as headache, dizziness, anxiety, drowsiness, nervousness and diarrhea, which is why it’s recommended to add them choline, which also increase potency of them.
The complete list of racetams: Brivaracetam, Aniracetam, Etiracetam, Dimiracetam, Coluracetam, Nicoracetam, Fasoracetam, Nefiracetam, Imuracetam, Nebracetam, Levetiracetam, Rolipram, Oxiracetam, Pramiracetam, Phenylpiracetam, Piracetam, Phenotropil, Seletracetam and Rolziracetam.
TOP 3 RACETAMS:
Piracetam was the first racetam made around 50 years ago, when people used it for epilepsy. Nowadays, biohackers use it to boost their cognitive enhancement. The most popular brand names for Piracetam are Nootropil and Lucetam.
Currently (August 2016), Piracetam is legal in the USA, while it hasn’t been approved by theFDA. It does not require a prescription to possess it. It is also legal in Canada, Australia (prescription, but can have it for personal use), China, Belgium, Russia, Czech Republic and a lot of other countries.
Sometimes Piracetam can cause headache, drowsiness, anxiety, diarrhea or nervousness, which is why it’s recommended to add other nootropics, that can prevent Piracetams’ side effects.
The recommended dosage for Piracetam is from 1 gram to 3 grams, not more than 3x a day.
Aniracetam was developed around 40 years go by the Hoffman-La Roche company. It is touted to be more potent than Piracetam and more catered to creativity, while it also helps at reducing anxiety and depression.
Each country has it’s own government agencies and laws to regulate nootropics and drugs. Aniracetam is currently (August 2016) unregulated in USA, which means it hasn’t been approved by the Food and Drug Administration (FDA), but it’s not illegal to possess it, which why it is in so called “grey area”. It is also unregulated in Canada, Australia, Germany and a lot of other countries.
Aniracetam’s side effect are: headache, nausea, vertigo, diarrhea and insomnia. That’s why it is good to use it with other nootropics to kill the side effects of Aniracetam.
The recommended dosage for Piracetam is from 600 mg to 3 grams, not more often than every four hours.
Oxiracetam was developed around 25 years ago and since then, there have been numerous studies regarding Oxiracetam, which have reported that even high dosage of Oxiracetam is safe over a long period of time.
It targets the two main neurotransmitters callled Glutamate and Acetylcholine. That’s why it helps you think and focus much more effectively, because Acetylcholine is increased.
However, Oxiracetam is currently still not approved by the FDA in United States of America. It is also not illegal in the most countries, but it’s good to check before ordering.
Unlike other brain enhancers, it is not used as a mood enhancer, because it doesn’t have any effects of serotonin or dopamine, which means it’s not used as a treatment for depression. It should be used only to improve cognitive function.
Oxiracetam is safe, since it’s non-toxic. Possible side effects are:
dizziness, nervousness, insomnia, headaches and nausea.
The recommended dosage for Piracetam is from 750 milligrams to 1,5 gram, every seven hours.
All of racetams do share common benefits, while each of them has it’s traits and nuances. It’s like a wine, they are all good, but have different tastes and colors, that make them special. Some racetams are focus enhancers, some are stimulators and some are more suited for creative thinking. They pretty much possess an anti-amnesiac ability, but it’s still unknown how much they can enhance cognition above normal.
Nootropics And Students
Written by: Peter Jamnik | Posted by: NootBot Editorial Staff
Nowadays, there is a huge competition on every university in the world. Studying all day doesn’t place you on the higher rank of students, since everybody on the elite universities (Stanford, Harvard, Oxford, etc.) can do that. Why? Because cost per year can be over $ 40.000, professors know no mercy, parents are nervous and all friends are counting on you. That’s why studying 24/7 isn’t enough.
You have to be much more effective and faster than others. That’s why students start taking nootropics and smart drugs (huge difference!) to outrun their classmates and get to the top of the top.
Numbers say, that 25% of students at Oxford univesity take smart drugs, such as Modafinil (Provigil) and Adderall. That being said, not taking any smart drugs or nootropics, means that you have much lower chances to get into the top of the top (if it’s even possible).
Most popular “Study Drugs”:
Modafinil is a smart drug, which could be the closest to NZT-48 from the movie Limitless in which Bradley Cooper goes from the bankrupted writer to a superstar broker.
It is a prescription drug, which is used to treat disorders such as narcolepsy, excessive daytime sleepiness and work sleep disorder. Modafinil is used as a wakefulness-promoting agent as well as cognition-enhancing agent. Some of the brand names of modafinil are Provigil, Modavigil and Alertec.
There are several reasons why this drug falls into the schedule IV in USA:
Possible side effect: headache, numbness, peeling, fever and muscle weakness “Emotional killer”, because it can unbalance your emotions. As an example: there are several report where people stop hanging out with their friends, because they think “it’s a waste of time” and just want to work 24/7 (which is actually almost possible with Modafinil).
It can cause addictiveness, because it takes you to the next level and you do become “better version of yourself” and you want to stay there. The problem is in the tolerance, because your body gets used to the substance and need to take it every day to stay at the same level. Taking the same amount every day is not enough, because you need to take more and more each day. That leads to burnout.
But besides that, it’s really not hard to get Modafinil, since you can buy it on the web. In the most cases, cost per pill is around one dollar, which is even cheaper than a cup of coffee, while it gives you 10 times more energy than coffee.
Noopept originates from Russia, where it is a prescription drug. It has a similar chemical structure to Piracetam, while it still doesn’t fall into the Racetam family. Noopept is one of the strongest and the most effective nootropics currently on the market and it’s legal in the USA (also you don’t need a prescription for it, but it’s still not FDA approved).
Noopept is the best for improving focus and memory, but there may appear side effects if used alone, such as: agitation, restlessness, irritability, dizziness and asthenia.
To prevent the side effects of Noopept, it’s good to add choline source, such Alpha GPC or Citicoline.
It is recommended to start with a lower dosage of Noopept (5 mg, max three times a day) and then slowly higher the dosage, so that you get to the recommended dosage from 10 to 30 mg per day.
Piracetam (Nootropil or Lucetam), the oldest of racetam family, was first used as a epilepsy drug around 50 years ago. Piracetam is even more reachable than Modafinil in USA, because it’s legal. There are a lot of companies that produce it and ship it worldwide and prices are just a few $ per gram.
Scientists believe, that piracetam effects cerebral cortex with optimizing and protecting it. It is known for improving focus,, memory, mood and motivation levels, because it can easily cross the blood-brain barrier and interact with glutamate and acetylcholine receptors.
It is really hard to overdose on piracetam, because it is water-soluble, any excess amounts are flushed through the urinary tract. There are no reports of overdosing on piracetam.
The lowest dosage recommended for piracetam is at around 400 mg, which is good for a start. The average dosage reported by users is around 800 mg of Piracetam, which can be repeated 3 times a day.
Possible side effects of Piracetam are: headache, nervousness, anxiety and drowsiness. To prevent these kind of side effects, it’s good to add some choline supplement, which prevents depletion of acetylcholine levels in the brain.